Week 6 of Thursday Night Football features an NFC West matchup between the San Francisco 49ers (-3, 47.5) and Seattle Seahawks at 8:15 p.m. ET. The NFL DFS player pool includes stars like Deebo Samuel, Brandon Aiyuk, Brock Purdy, DK Metcalf and Geno Smith, so who should you include in your Thursday Night Football NFL DFS picks? Before setting your NFL DFS lineups on sites like DraftKings and FanDuel, you NEED to see what Mike McClure has to say.

McClure is a legendary professional DFS player with more than $2 million in career winnings. He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends, and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine. His methodology has led to enormous cashes on FanDuel and DraftKings, including. Last year, he won the DraftKings Millionaire Maker twice and the FanDuel Million once. Anyone who has followed him is way up!

Now, McClure has turned his attention to 49ers vs. Seahawks on Thursday Night Football and locked in his top daily Fantasy football picks. 

We can tell you one of McClure's top NFL DFS picks for Thursday Night Football is 49ers running back Jordan Mason. Part of McClure's optimal NFL DFS strategy also includes rostering Seahawks running back Kenneth Walker, who is averaging 100.3 total yards per game this season. He has four touchdowns over three games and is an integral part of the offense in the rushing and passing attack. Walker rushed for at least 80 yards in his first two games and had seven receptions for 57 yards against the Giants last week. 

McClure is also targeting an undervalued player who could go off for MASSIVE numbers on Week 6 Thursday Night Football! This pick could be the difference between winning your tournaments and cash games or going home with nothing! You ABSOLUTELY need to see who it is before locking in any lineups.

What are the top NFL DFS picks Seahawks vs. 49ers? And which under-the-radar player is a MUST-ROSTER? ... Join SportsLine now to see DFS pro Mike McClure's top picks, stacks, and player pools for sites like FanDuel and DraftKings, and cash in BIG on NFL DFS!